As a researcher who spends my days wrestling with HPLC columns, mass spectrometry data, and complex amino acid sequences, I fully understand the "walking on thin ice" feeling when sourcing Melanotan II (MT-II) raw materials. At Shaanxi Sunrise Pharmaceutical Co., Ltd., we define industry benchmarks through extreme purity.
What is the biochemical essence of Melanotan II raw material?
If you believe Melanotan II (CAS No: 121062-08-6) is merely a "tanning powder," you are significantly underestimating the precision of peptide chemistry. MT-II is a synthetic cyclic heptapeptide analog of the naturally occurring α-MSH.
Molecular Formula: C50H69N15O9
Stability: By replacing the 7th amino acid with D-Phe7, we grant it potent resistance to enzymatic degradation.
Pro-Tip: "Cyclization stability" is the core metric. Incomplete cyclization leads to disastrous deviations in experimental data.
How does high-purity MT-II regulate health via the MC1R pathway?
MT-II acts as a "signal switcher." By precisely agonizing the MC1R (Melanocortin 1 Receptor), it induces melanocytes to secrete Eumelanin.
Unlike Pheomelanin, Eumelanin acts as a natural "biological umbrella," increasing the Minimum Erythema Dose (MED). This builds a defense line at the cellular level, reducing DNA strand breaks caused by UV radiation.
Why is MT-II a "gold standard" in metabolism and obesity research?
High-activity Melanotan II powder can cross the blood-brain barrier and act on the energy regulation center of the hypothalamus via MC4R.
It generates a strong satiety signal to suppress appetite and promotes thermogenesis in brown adipose tissue. APIs with purity above 99% simulate this physiological process with extreme precision, avoiding interference from residual organic solvents like TFA.
What are the contributions of MT-II to CNS-mediated sexual health?
MT-II acts as a "precision tuner" for brain signals in the MC3R/MC4R neural circuits. Unlike traditional vasodilators, this "brain-to-body" regulation is more natural. This requires "ruthless" control of Endotoxins in the raw material to ensure subject safety during neurogenic impairment research.
How should we objectively evaluate side effects and human tolerance?
| Side Effect | Biological Mechanism | Research Note |
|---|---|---|
| Gastrointestinal Stress | Receptors in intestinal smooth muscle | High purity reduces chemical irritation but doesn't eliminate feedback. |
| Dynamic Mole Changes | Hyperpigmentation of existing melanin | Requires strict monitoring to avoid masking skin lesions. |
| Systemic Risks | Overdose or low-grade materials | Risk of blood pressure fluctuations or rhabdomyolysis. |
How to identify high-purity MT-II?
A trustworthy Certificate of Analysis (COA) must include:
RP-HPLC Purity: Main peak area ≥98.0%.
Mass Spectrometry (MS): Molecular weight exactly 1024.2 ±1.
TFA Residual Testing: Premium materials must keep this < 10%.
Why choose Shaanxi Sunrise Pharmaceutical Co., Ltd.?
We are the guardians of scientific standards in the Peptide API market:
Exquisite Craftsmanship: "Solid-Liquid Hybrid Three-Step Purification" ensuring 99.0% - 99.8% purity.
Rigorous QC: Equipped with Agilent LC systems and heavy metal detection.
Vacuum Freeze-Drying: Ensures "zero loss" of biological activity during global transit.
References:
NCBI - Melanotan II Research Overview: 15262698
Hadley, M. E., & Dorr, R. T. (2006). Melanocortin peptide therapeutics
PubChem: Compound Summary for MT-II