Melanotan II (MT II) Powder | CAS No: 121062-08-6 | Pharma Raw Material
Melanotan II (MT II) Powder | CAS 121062-08-6 | Pharma Raw Material,CAS 121062-08-6, Pharma Raw Material,Melanotan II (MT II) Powder | CAS 121062-08-6
Content
Product Introduction
 | English Name: Melanotan II Synonyms: MT-2; MT2; Melanotan II Product Purity ：≥98.0% Product Appearance: white powder Single Impurity：≤2% Acetate Content ≤12.0% Moisture Content ≤ 8.0% Peptide Content ≥ 80.0% Amino Acid Composition Analysis ≤±10% Bacterial Endotoxins≤50EU/mg CAS No: 121062-08-6 Molecular Formula: C50H69N15O9 Molecular Weight: 1024.18 EINECS No：1308068-626-2 Declaration of Use: This product is intended for industrial use or scientific research only. |
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Product Description
Melanotan II (MT-2) is a synthetic cyclic analog of α-melanocyte-stimulating hormone (α-MSH). Through molecular structure optimization (N-terminal acetylation, C-terminal amidation, and cyclic modification of amino acids at positions 4 and 10), it significantly enhances biological activity and degradation resistance, serving as a highly specific research tool for melanocortin receptors in the scientific community.
As a core research-grade peptide product of Shaanxi Sunrise Pharma, this product is manufactured in strict compliance with GMP standards and prepared via multiple purification processes to ensure high purity and low impurity levels. It appears as a white powder, readily soluble in dimethyl sulfoxide (DMSO) and exhibiting good solubility in neutral buffers, providing stable performance guarantees for in vitro and in vivo research.
Core Technical Parameters: Purity ≥98.0%, Single Impurity ≤2.0%, Peptide Content ≥80.0%, Acetate Content ≤12.0%, Moisture Content ≤8.0%, Bacterial Endotoxins ≤50EU/mg, Amino Acid Composition Analysis Deviation ≤±10%, fully meeting research-grade experimental requirements.
CAS No.: 121062-08-6 | Molecular Formula: C₅₀H₆₉N₁₅O₉ | Molecular Weight: 1024.18 | EINECS No.: 1308068-626-2
Usage Declaration: This product is intended for industrial production or scientific research only. It is not for medical or food use, and strictly prohibited for human clinical trials, diagnosis, or treatment. Shaanxi Sunrise Pharma shall not be liable for any illegal use, and the user shall bear full responsibility.
Compliance & Storage Instructions: Store sealed at -20℃ in a frozen environment, protected from light, moisture, and heat sources. Avoid repeated freeze-thaw cycles during storage; shelf life is 2 years (from the batch number date). Transported in dry ice refrigerated packaging, complying with UN3373 biological reagent transport standards. The supply of this product strictly adheres to ICH Q7 API manufacturing guidelines, and is only provided to institutions with legitimate scientific research or industrial qualifications. Relevant qualification certificates are required when placing orders.
Pharmacological Action
As a non-selective melanocortin receptor (MCRs) agonist, MT-2 efficiently activates four receptor subtypes (MC₁R, MC₃R, MC₄R, and MC₅R) and exerts multiple pharmacological activities through multi-target regulation. Its core pharmacological effects are reflected in three dimensions:
Pigment Metabolism Regulation: Specifically binds to MC₁R on the surface of skin melanocytes, activates the melanin synthesis pathway, enhances tyrosinase activity, accelerates the formation and transport of melanosomes, and regulates skin pigmentation.
Metabolism & Appetite Regulation: Crosses the blood-brain barrier and acts on hypothalamic MC₄R, regulates the expression of neuropeptide Y (NPY) and pro-opiomelanocortin (POMC), inhibits the activity of the appetite center, promotes energy consumption, and participates in the regulation of body weight and glucose-lipid metabolism balance.
Anti-Inflammatory & Neuroprotective Effects: Inhibits the NF-κB signaling pathway by activating MC₃R/MC₄R, reduces the release of pro-inflammatory factors such as TNF-α and IL-6, and promotes the expression of brain-derived neurotrophic factor (BDNF), exerting anti-inflammatory, antioxidant, and neuroprotective effects.
Mechanism of Action
The biological effects of MT-2 are based on the core molecular pathway of "receptor activation - signal transduction - gene regulation", with its precise mechanism of action as follows:
Receptor Binding Initiation: MT-2 enhances binding affinity with MCRs through its intramolecular cyclic structure, specifically recognizes receptors on the surface of target cells to form complexes, and activates intracellular G protein-coupled signaling pathways.
Intracellular Signal Amplification: Activates adenylate cyclase (AC), catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP), and the increased cAMP level activates protein kinase A (PKA), which in turn phosphorylates microphthalmia-associated transcription factor (MITF).
Downstream Effect Implementation: Phosphorylated MITF enters the nucleus to regulate the transcription of key melanin synthesis enzyme genes (tyrosinase, TRP-1); meanwhile, it regulates intracellular calcium ion concentration through the PLC-IP₃-DAG pathway, achieving precise regulation of physiological processes such as appetite and inflammatory response.
Auxiliary Pathway Regulation: Upregulates phosphatase and tensin homolog (PTEN), inhibits the AKT signaling pathway, and further participates in the fine regulation of cell proliferation, apoptosis, and metabolic balance.
Product Efficacy
Relying on precise molecular mechanism of action and high-purity quality, MT-2 demonstrates three core efficacies in scientific research scenarios, providing strong support for multi-field research:
🔅 Skin Photoprotective Efficacy
Efficiently promotes endogenous melanin production, enhances the skin's natural defense against ultraviolet (UV) rays, reduces photodamage and oxidative stress, providing experimental models for the research of pigmentary disorders such as vitiligo and albinism.
⚖️ Metabolic Regulation Efficacy
Significantly inhibits the activity of the appetite center, reduces energy intake, and promotes fat decomposition and energy consumption, serving as a target verification tool for the research on the pathogenesis and drug development of metabolic diseases such as obesity and type 2 diabetes.
🧠 Neuroprotective Efficacy
Through anti-inflammatory, antioxidant, and neurotrophic factor regulation, it reduces ischemic damage to nerve cells, providing potential intervention directions for the research of neurodegenerative diseases such as ischemic stroke and Parkinson's disease.
Product Application
As a highly active research-grade peptide raw material, MT-2 is widely used in medical research, drug development, and basic physiological mechanism exploration. Its core application scenarios include:
Pigmentary Disorder Research: Used in the research on melanocyte function regulation of diseases such as vitiligo and chloasma, evaluates the intervention effect of exogenous peptides on pigment repair, and provides experimental basis for the development of topical or injectable repair drugs.
Anti-Obesity Drug Development: As a standard MC₄R agonist, it is used to screen highly selective MC₄R-targeted drugs, verify the appetite suppression and weight regulation activity of candidate compounds, and optimize drug molecular structures.
Neuroscience Research: Applied in the construction of models such as ischemic brain injury and neuroinflammation, explores the protective mechanism of peptides on the central nervous system, and provides theoretical support for the development of neuroprotective drugs.
Receptor Pharmacology Research: As a broad-spectrum agonist of the melanocortin receptor family, it is used for receptor binding activity detection, signal pathway analysis, and receptor subtype specificity research, providing positive controls for pharmacological experiments.
Industrial Scientific Research Application: Used in cosmetic raw material research and development (skin photoprotective ingredient screening) and biological reagent standard preparation, providing high-quality raw material support for industrial-grade peptide applications.