Cosmetic grade Oligopeptide-1 Peptide Oligopeptide-1

Product Introduction

Product Name: Oligopeptide-1 API Product Purity: ≥99.0% Product CAS No :72957-37-0 Detection Method: HPLC Molecular Formula: C₁₆H₂₈N₆O₆ Molecular Weight: 396.43 g/mol EINECS No : 277-597-4 Product Appearance: White to off-white fine powder, odorless, easily soluble in water Product Packaging: 1KG in aluminum foil bag; 25KG/drum（Customizable） Product Storage: Sealed and stored in a cool, dry and dark place at 2-8℃, avoid moisture, heat and contact with oxidants Shelf Life: 24 months   Declaration of Use: This product is intended for industrial use or scientific research only.

Products Description  

Oligopeptide-1 (CAS No.:72957-37-0) is a natural bioactive tripeptide composed of Glycine-Histidine-Lysine, with a purity of ≥99.0% tested by HPLC and a molecular weight of 396.43 g/mol. It appears as a white to off-white fine powder, odorless and freely soluble in water. As a small-molecule peptide, it features strong skin permeability that allows it to penetrate the skin barrier and act directly on the dermal layer. It exerts multi-dimensional skin care effects by activating fibroblast signaling pathways, stimulating extracellular matrix (ECM) synthesis and regeneration, and regulating collagen metabolism. This high-purity Oligopeptide-1 is a premium raw material for high-end cosmetic formulations, with stable biological activity and good compatibility with most cosmetic base materials.

Products  Advantages

1. Ultra-high purity & high bioactivity：≥99.0% purity detected by HPLC, minimal impurities, ensures the maximum biological activity of the active peptide and avoids skin irritation caused by impurities.

2. Small molecule & strong transdermal penetration：Tripeptide molecular structure with small molecular weight, can directly penetrate the skin barrier to act on dermal fibroblasts, no need for complex embedding technology to exert efficacy.

3. Multi-functional & high cost performance：Integrates anti-aging, firming, skin repair and other core effects, a single raw material can meet multiple cosmetic formulation needs, reducing formula development costs.

4. Good formula compatibility：Suitable for the mainstream cosmetic formula system (water-based, cream-based), can be synergistically compounded with most active ingredients such as hyaluronic acid and vitamin C derivatives.

5. Stable storage & easy processing：Stable under the condition of sealed, cool and dry storage (2-8℃), with a shelf life of 24 months; the recommended processing temperature is <40℃, which is in line with the conventional cosmetic production process.

Products Function

1. Stimulate ECM protein synthesis：Activate TGF-β, MAPK and other signaling pathways in skin fibroblasts, significantly promote the synthesis of collagen Type I & III, elastin, fibronectin and laminin, and increase skin collagen content by 30%-50%.

2. Enhance skin elasticity and firmness：Improve the density of the dermal matrix, reduce dynamic wrinkles and static wrinkles, and alleviate skin laxity, making the skin tight and elastic.

3. Promote skin tissue repair and barrier regeneration：Up-regulate the expression of TIMPs, inhibit collagen degradation, accelerate the healing of skin micro-wounds, and repair the damaged skin barrier, suitable for sensitive skin and post-procedural skin care.

4. Synergistic antioxidant and anti-photoaging：Although the free form has weak antioxidant activity, it can form GHK-Cu with low-concentration copper ions, which effectively scavenges ROS (Reactive Oxygen Species) and alleviates skin photoaging damage caused by free radical oxidation.

Products Aplication

Oligopeptide-1 is widely used in high-end skin care products, with different recommended addition concentrations for different cosmetic categories, adapting to the characteristics of different skin parts and care needs:

1. Anti-aging skin care products：Serums, face creams, anti-aging essences; recommended concentration: 0.01%-0.1%; core effect: improve facial wrinkles, skin laxity and rough skin.

2. Skin repair products：Post-procedural repair masks, sensitive skin care serums, soothing creams; recommended concentration: 0.01%-0.08%; core effect: accelerate skin barrier regeneration and soothe fragile skin.

3. Eye care products：Eye serums, eye creams, eye masks; recommended concentration: 0.005%-0.02%; core effect: improve fine lines, dry lines and puffiness around the eyes, mild and non-irritating for delicate eye skin.

4. Daily moisturizing and firming products：Moisturizing essences, firming lotions; recommended concentration: 0.005%-0.05%; core effect: synergistically enhance skin firmness while moisturizing.

Products FAQ  

Q1: What is the difference between Oligopeptide-1 and human oligopeptide-1 (EGF)?

A: Oligopeptide-1 is a tripeptide composed of 3 amino acids (CAS:72957-37-0), which is allowed to be used in cosmetics worldwide and exerts effects by stimulating ECM synthesis. Human oligopeptide-1 (EGF) is a polypeptide of 53 amino acids, which is prohibited to be used as a cosmetic raw material in many countries (such as China) due to its strong cell proliferation effect, and the two are essentially different substances.

Q2: What is the recommended storage condition for Oligopeptide-1 raw material?

A: The raw material should be sealed and stored in a cool, dry and dark place at 2-8℃, avoiding moisture, high temperature and direct sunlight. Under the above storage conditions, the shelf life of the raw material is 24 months; after opening, it is recommended to use it up as soon as possible and avoid repeated freezing and thawing.

Q3: How to optimize the stability of Oligopeptide-1 in cosmetic formulations?

A: First, control the processing temperature below 40℃ during production to avoid peptide chain damage caused by high temperature; second, adjust the formula pH to 5.5-7.0 to avoid extreme acid-base environments; third, compound with polyols (such as glycerin, diethylene glycol) to enhance water solubility and stability; fourth, avoid adding strong oxidants and high-concentration metal ions.

Q4: Can Oligopeptide-1 be compounded with copper ions? What is the effect after compounding?

A: Oligopeptide-1 can be complexed with low-concentration copper ions to form GHK-Cu (Copper Peptide), which significantly enhances its antioxidant activity, ROS scavenging ability and skin repair effect; however, high-concentration copper ions will destroy the peptide chain structure of Oligopeptide-1 and reduce its biological activity, so the concentration of copper ions must be strictly controlled during compounding.

Q5: Why is the addition concentration of Oligopeptide-1 in cosmetics very low?

A: Oligopeptide-1 is a high-activity signal peptide, which exerts biological effects by activating the signaling pathways of skin fibroblasts, and a small amount can stimulate the synthesis of a large number of ECM proteins such as collagen. Excessively high addition concentration will not significantly improve the efficacy, but will increase the formulation cost and may cause potential skin irritation; in addition, the skin's transdermal absorption capacity is limited, and high-concentration addition cannot improve the absorption efficiency.