GLP-1 Peptide Powder | 99% Purity Antidiabetic

Product Introduction

Products Description  

GLP-1 (CAS No.: 87805-34-3), fully known as Glucagon-Like Peptide-1 (7-36) Amide, is the active form of endogenous incretin secreted by L cells in the human intestine, and also the dominant functional GLP-1 subtype in the human body. This product is precisely prepared by Solid-Phase Peptide Synthesis (SPPS) process, with a molecular formula of C₁₈₆H₂₇₅N₅₁O₅₉ and a precisely calculated molecular weight of 4113.48 g/mol. It appears as a white to off-white lyophilized powder, odorless and highly hygroscopic. Tested by HPLC normalization method, its purity is ≥99.0% with extremely low impurity content and no obvious degradation products. It can accurately simulate the biological activity of natural GLP-1 and stably bind to GLP-1 receptors, providing reliable raw material support for metabolic research and drug development, and complying with strict standards for biological reagents and pharmaceutical intermediates.

Products  Advantages

· Superior Purity and Activity Guarantee: With a purity of ≥99.0%, strictly tested by HPLC, the content of single impurity is precisely controlled. The lyophilization process locks in peptide activity, with an activity retention rate of over 99.5%, avoiding impurity interference on experimental or R&D results.

· Advanced Synthesis Process: Adopting Solid-Phase Peptide Synthesis technology, the amino acid sequence is precisely matched with the structure of natural GLP-1 (7-36) Amide without sequence deviation. The production process complies with basic GMP guidelines, ensuring excellent batch stability.

· Stability-Optimized Design: Aiming at high hygroscopicity, vacuum nitrogen-filled packaging combined with lyophilization technology is adopted, and the stability data has been strictly verified — under vacuum-sealed storage conditions at 2-8℃, the purity retention rate is ≥98.5% within 24 months, and the total amount of degradation products is ≤1.0%; when sealed and placed at room temperature (25℃) for 7 days, there is no significant purity decrease (≥99.0%), which can withstand short-term transportation temperature fluctuations; verified by 5 repeated freeze-thaw experiments, the activity retention rate is still ≥97%, greatly reducing the degradation risk during storage and transportation, and ensuring the stability of experiments and production.

· Customized Service Adaptation: Supports customization of small specifications (1g/10g/100g) and standard specifications (1KG/25KG). The packaging material and sealing method can be adjusted according to customer needs, adapting to different scenarios such as scientific research samples and pilot-scale production.

· Compliance and Traceability: Each batch of products is accompanied by a complete Certificate of Analysis (COA), including key indicators such as purity, molecular weight, and appearance. The production process is traceable, meeting the compliance review requirements of international research institutions and pharmaceutical companies.

Products Function

· Blood Glucose Regulation Function: As a GLP-1 receptor agonist, it can glucose-dependently promote insulin secretion from pancreatic β cells and inhibit glucagon release from pancreatic α cells, achieving precise blood glucose regulation with extremely low risk of hypoglycemia.

· Metabolic Regulation Effect: It can delay gastric emptying rate, act on the satiety center of the hypothalamus, reduce hunger, decrease calorie intake, assist in weight management, and provide target support for obesity mechanism research.

· Receptor Binding Activity: It can specifically bind to GLP-1 receptors and activate downstream signaling pathways, providing a standard control for the R&D and activity verification of GLP-1 receptor agonist drugs (such as Semaglutide).

· Scientific Reference Standard Function: Its high purity makes it usable as a reference standard in biochemical experiments for calibrating detection methods, verifying the reliability of experimental systems, and improving the accuracy of metabolic disease research data.

Products Aplication

· Scientific Research Field: Used in the mechanism research of diabetes, obesity, metabolic syndrome and other diseases. It can serve as a core reagent for cell experiments and animal experiments to explore the physiological functions and regulatory mechanisms of the GLP-1 pathway.

· Pharmaceutical R&D: As a pharmaceutical intermediate for the R&D of GLP-1 receptor agonist drugs (such as Semaglutide and Liraglutide), it is used in drug activity screening, formulation optimization and quality control.

· Biochemical Experiments: Used in the establishment of peptide drug detection methods, receptor binding experiments, activity verification experiments, etc., providing accurate reference substances for biopharmaceutical companies and third-party testing institutions.

· Teaching and Quality Inspection: Can be used as teaching experiment material for biochemistry and pharmacology in colleges and research institutes, as well as for the calibration and comparison of quality control reference substances in the pharmaceutical industry.

Products FAQ

Q: How is product purity guaranteed? What items are included in the test report?

A: The product purity is strictly tested by HPLC normalization method to ensure ≥99.0%. Each batch is accompanied by a complete COA, including key items such as purity, molecular weight, appearance, moisture content, impurity content and activity verification. The production batch and testing process are traceable, meeting the compliance requirements of scientific research and pharmaceutical companies.

Q: How to store the product after opening to avoid moisture absorption and degradation?

A: The product is highly hygroscopic. After opening, it should be used immediately in a dry and clean environment (humidity ≤40% is recommended). The remaining part should be vacuum-sealed, added with new desiccant, and stored in a refrigerator at 2-8℃, avoiding repeated freeze-thaw. It is recommended to use it up within 1 month after opening to ensure activity.

Q: Can small-batch samples be provided for experimental verification? How is the sample freight calculated?

A: Small-batch samples (1g/10g) are available, and the sample fee is negotiable, with freight borne by the customer. Samples are shipped via FedEx/UPS sensitive goods dedicated cold chain, with full temperature control to ensure sample activity, and can be delivered to major international research institutions in 5-7 days.

Q: Is the product only for scientific research, and does it involve FDA regulatory restrictions on clinical use?

A: This product is clearly marked as "For Scientific Research Only, Not for Clinical Treatment, Diagnosis or Human Consumption", strictly complying with international regulatory requirements. As a scientific research reagent, it does not require FDA approval for clinical use. However, if the customer uses it for clinical-related R&D, they must complete the filing and approval procedures with local regulatory authorities independently.

Q: Are special customs clearance documents required for export to the US and Europe?

A: Yes. We will assist in preparing a full set of compliant documents in advance, including COA, product safety assessment report, certificate of origin, foreign trade contract, packing list, etc.; additional FDA import filing documents are required for export to the US, and REACH-compliant declarations are provided for export to Europe to ensure smooth customs clearance.