99% Purity Retatrutide Powder Retatrutide

Product Name: Retatrutide Powder API Alternative Names：LY3437943,Ruitatide ，Retatrutide ，Triple-G agonist Product Purity: ≥99.0% Product CAS No :2381089-83-2 Detection Method: HPLC Molecular Formula: C₂₁₉H₃₃₄N₅₈O₅₉S₂ Molecular Weight: 4728.47 Da Peptide Sequence ：39-amino acid synthetic peptide (GLP-1/GIP/glucagon triple agonist) EINECS No : 200-001-8 Product Appearance: White to off-white lyophilized powder Product Packaging: Aluminum foil bag or lyophilized vial, custom packaging available Product Storage: Store at -20°C, sealed and protected from light Shelf Life: 24 months   Declaration of Use: This product is intended for industrial use or scientific research only.

Products Description  

Retatrutide is a groundbreaking synthetic peptide API developed by Eli Lilly, acting as a long-acting triple receptor agonist that simultaneously targets GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. This innovative "Triple-G" mechanism offers synergistic metabolic regulation beyond traditional single or dual agonists.

Our Retatrutide Powder API is manufactured using advanced peptide synthesis and lyophilization technologies, ensuring exceptional purity ≥99.0% and structural integrity. Each batch undergoes rigorous quality control to meet pharmaceutical research standards, providing consistent performance for your drug development projects.

Products  Advantages

1. Triple Receptor Synergy: Unique activation of GLP-1, GIP, and glucagon receptors for comprehensive metabolic control, potentially outperforming single-target therapies

2. Superior Purity: ≥99.0% purity verified by HPLC-MS, minimizing impurities that could affect research results

3. GMP Compliance: Manufactured in a GMP-certified facility with strict quality management systems

4. Batch Consistency: Advanced production processes ensure minimal batch-to-batch variation

5. Long-Term Stability: Lyophilized powder form maintains stability for 24 months at -20°C

6. Versatile Application: Suitable for various research models and formulation development

7. Expert Technical Support: Comprehensive documentation and professional assistance from our peptide specialists

Products Function

 Core Pharmacological Functions

• Triple Receptor Synergistic ActivationSimultaneously binds to and activates GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), and glucagon receptors. This "Triple-G" mechanism achieves more comprehensive metabolic regulation than traditional single or dual receptor agonists, breaking through the limitations of single-target interventions.

• Targeted Weight Management RegulationInhibits appetite by regulating hypothalamic hunger signals, reduces energy intake, promotes lipolysis and fat oxidation, and decreases adipose tissue accumulation. It shows significant potential in preclinical studies for obesity intervention and weight loss mechanism research.

• Blood Glucose Homeostasis MaintenanceExerts glucose-dependent insulinotropic effects: enhances insulin secretion when blood glucose is elevated, inhibits glucagon release to reduce hepatic glucose production, and improves insulin sensitivity in peripheral tissues (muscle, adipose). It effectively stabilizes blood glucose levels without increasing the risk of hypoglycemia.

• Lipid Metabolism OptimizationReduces serum triglyceride, total cholesterol, and low-density lipoprotein (LDL) levels, while increasing high-density lipoprotein (HDL) content. It also inhibits hepatic lipid synthesis and accumulation, providing research support for metabolic-associated fatty liver disease (MASLD/NASH) intervention.

• Energy Metabolism EnhancementActivates thermogenic pathways in brown adipose tissue, increases basal metabolic rate, and promotes energy expenditure. It helps improve metabolic sluggishness and breaks the cycle of energy imbalance in metabolic diseases.

Research Application Functions

As a high-purity research-grade API, Retatrutide provides critical support for various preclinical research scenarios, with the following core application functions:

1. Metabolic Disease Mechanism Research: Used to explore the pathogenesis of obesity, type 2 diabetes, MASLD/NASH, and cardiometabolic diseases, and identify potential therapeutic targets.
      

2. Peptide Therapeutic Development: Serves as a lead compound for triple receptor agonists, supporting structural optimization, long-acting formulation development (e.g., sustained-release injectables), and pharmacodynamic verification of novel metabolic drugs.
      

3. Pharmacological Efficacy Evaluation: Enables in vitro cell experiments and in vivo animal model studies to assess the impact of triple receptor activation on metabolic indicators (body weight, blood glucose, lipids), providing data support for preclinical trials.
     

4. Receptor Binding Characteristics Study: Facilitates research on receptor binding affinity, signal transduction pathways, and structure-activity relationships of GLP-1, GIP, and glucagon receptors, laying a foundation for basic pharmaceutical research.

5. Combination Intervention Research: Can be used in combination with other metabolic regulators (e.g., SGLT-2 inhibitors, GLP-1 single agonists) to explore the synergistic effects of multi-target interventions on metabolic diseases.      

Products Application

1. Obesity Research: Investigation of weight loss mechanisms and potential therapeutic interventions

2. Type 2 Diabetes Studies: Evaluation of glucose regulation and insulin sensitivity enhancement

3. Metabolic Associated Fatty Liver Disease (MASLD/NASH): Research on liver fat reduction and metabolic health improvement

4. Cardiometabolic Health: Assessment of cardiovascular risk factor modulation

5. Peptide Therapeutics Development: Formulation studies for novel injectable or long-acting delivery systems

6. Pharmacokinetic/Pharmacodynamic Research: Investigation of absorption, distribution, metabolism, and excretion profiles

Quality Control Standards

Products FAQ

Q1: What is Retatrutide, and what is its core mechanism of action?

A: Retatrutide (CAS 2381089-83-2, also known as LY3437943) is a synthetic long-acting triple receptor agonist peptide developed by Eli Lilly. Its core mechanism is to simultaneously activate GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors in the human body, achieving synergistic regulation of metabolism—this "Triple-G" effect is more comprehensive than traditional single/dual receptor agonists, making it a key research material for metabolic diseases.

Q2: How do you verify the ≥99.0% purity of Retatrutide, and do you provide test reports?

A: We use HPLC (High Performance Liquid Chromatography) combined with MS (Mass Spectrometry) to verify the purity of Retatrutide, which is the gold standard for peptide purity detection in the pharmaceutical industry. Each batch of products is accompanied by a Certificate of Analysis (CoA) that details purity, identity, moisture content, endotoxin, heavy metal and other test results—all data are traceable and meet international pharmaceutical research standards.

Q3: What are the main research applications of Retatrutide? Is it suitable for clinical human therapy?

A: Retatrutide is mainly used for preclinical research in: ① Obesity mechanism and therapeutic intervention; ② Type 2 diabetes glucose regulation research; ③ MASLD/NASH (metabolic-associated fatty liver disease) research; ④ Cardiometabolic health assessment. Important Note: Our Retatrutide is for research use only (RUO), not for human/veterinary therapeutic applications, and does not comply with clinical drug registration standards.

Q4: What are the optimal storage conditions for Retatrutide, and how to ensure its shelf life?

A: The optimal storage conditions for Retatrutide lyophilized powder are: sealed, protected from light, and stored at -20°C (avoid repeated freezing/thawing). Under this condition, the shelf life is 24 months. For transportation: ① International orders use dry ice cold chain to maintain low temperature; ② Domestic orders use insulated packaging with desiccant. We will attach a temperature indicator to the package to confirm the transportation environment is compliant.

Q5: Is your Retatrutide GMP-compliant, and what compliance documents are provided for global export?

A: Our Retatrutide is produced in a GMP-certified facility with strict quality management throughout the production process (from raw material selection to lyophilization). For global export, we can provide: ① Certificate of Analysis (CoA); ② Certificate of Origin (CO); ③ MSDS (Material Safety Data Sheet); ④ Non-hazardous cargo certification; ⑤ Customized documents (e.g., free sales certificate) according to the import requirements of different countries (EU/USA/Japan etc.).