Product Name: Desloratadine Powder Product Purity: ≥98% CAS No.: 100643-71-8 Molecular Formula: C₁₉H₁₉ClN2 Molecular Weight: 310.85 Testing Method: HPLC Active Ingredient: Desloratadine Product Characteristics: White to off-white crystalline powder Product Packaging: 1kg/bag; 25kg/drum Storage Conditions: Protect from light, keep sealed, store in a cool, dry place Shelf Life: 24 months Declaration of Use: This product is intended for industrial use or scientific research only.

Products  Description

Desloratadine Powder is a high-purity synthetic antihistamine drug substance, serving as the active metabolite (de-ethoxycarbonyl derivative) of Loratadine. The product appears as a white to off-white crystalline powder, odorless or with a faint characteristic odor; extremely low water solubility (approximately 0.1 mg/mL), readily soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO); purity ≥98% (High Performance Liquid Chromatography, HPLC).

Products Function

The core function of desloratadine powder is to selectively inhibit histamine-mediated allergic reactions, specifically including:

1. Blocking H₁ receptor signaling: By highly selectively binding to histamine H₁ receptors in peripheral tissues (such as nasal mucosa, skin, and gastrointestinal tract), it prevents histamine from binding to its receptors. This inhibits histamine-induced vasodilation, increased permeability, smooth muscle contraction (e.g., nasal congestion, skin urticaria), and glandular secretion (e.g., rhinorrhea, lacrimation).

2. Non-sedating effect: Due to its molecular structure that does not readily cross the blood-brain barrier, it minimally affects H₁ receptors in the central nervous system, resulting in virtually no common adverse reactions of first-generation antihistamines such as drowsiness or fatigue;

3. Adjuvant anti-inflammatory effects: Inhibits the release of inflammatory mediators like leukotrienes and prostaglandins from mast cells and eosinophils, thereby reducing inflammatory damage in allergic reactions (e.g., nasal mucosal swelling in allergic rhinitis, skin redness and swelling in urticaria).

Products Application

Desloratadine powder is used in foreign trade exports, scientific research, and chemical reagents.

Mechanism of Action

The mechanism of action of desloratadine involves multidimensional inhibition of allergic reactions, with its core function being selective peripheral H₁ receptor blockade.