7-Ketolithocholic Acid (CAS 4651-67-6) | High-Purity 7-KLCA Intermediate
7-Ketolithocholic Acid (CAS 4651-67-6) | High-Purity 7-KLCA Intermediate
7-Ketolithocholic Acid,7-KLCA,CAS 4651-67-6,3α-Hydroxy-7-oxo-5β-cholanic Acid,Bile Acid Intermediate,UDCA precursor,7-Oxolithocholic Acid,Obeticholic Acid synthesis
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Description
3α-Hydroxy-7-oxo-5β-cholanic Acid (7-KLCA)
High-Purity Bile Acid Intermediate | CAS 4651-67-6
Handling & Storage: Stable in sealed, dry, light-proof conditions. Avoid prolonged exposure to moisture and high temperatures. Long-term storage below 15°C is recommended. Non-hazardous transport.
Product Overview
3α-Hydroxy-7-oxo-5β-cholanic Acid, commonly known as 7-Ketolithocholic Acid (7-KLCA), is a premium steroid bile acid derivative. Produced via advanced synthetic and purification processes, our product undergoes rigorous quality testing to ensure exceptional structural stability, high purity, and batch-to-batch consistency. It serves as an irreplaceable upstream raw material for high-value medications and a vital research tool for exploring the gut-liver axis.
| Official IUPAC Name | 3α-Hydroxy-7-oxo-5β-cholan-24-oic Acid |
|---|---|
| Common Synonyms | 7-KLCA, 7-Oxolithocholic Acid, Nutriacholic Acid |
| CAS Number | 4651-67-6 |
| MFCD / EINECS Number | MFCD00271393 / 225-083-2 |
| Molecular Formula | C24H38O4 |
| Molecular Weight | 390.56 g/mol |
| Appearance | White to off-white crystalline powder, odorless |
| Melting Point | 197–206 °C (Batch-specific data in COA) |
| Specific Optical Rotation | -27.0° to -31.0° (C=2, Ethanol, 20°C) |
| Solubility | Insoluble in water; Soluble in DMSO, ethanol, chloroform, methanol |
Quality Grades & Specifications
We offer tailored purity grades to match laboratory research, pilot scale-up, and large-scale industrial production. Full traceable documentation (COA, SDS, HPLC, NMR/IR) is provided for every batch.
| Product Grade | HPLC Purity | Strict Quality Control Standards |
|---|---|---|
| Lab Research Grade | ≥ 97.0% | • Single impurity ≤0.1% • Total impurities ≤1.0% • Loss on drying ≤1.0% • Heavy metals ≤10 ppm • Residue on ignition ≤0.1% • NMR & IR spectra fully match standard |
| Pharma Intermediate Grade | ≥ 98.5% | |
| High-Purity Grade | ≥ 99.0% |
Core Applications
1. Pharmaceutical Synthesis (UDCA/OCA)
An irreplaceable precursor for synthesizing blockbuster bile acid drugs, including Ursodeoxycholic Acid (UDCA) and Obeticholic Acid (OCA). Its standardized structure ensures high conversion efficiency and minimal impurity formation in downstream synthesis.
2. Biochemical & Metabolic Research
As a natural endogenous metabolite produced by intestinal flora, 7-KLCA serves as a reliable probe for exploring bile acid pool regulation, hepatic metabolism, gut-liver axis crosstalk, and FXR/TGR5 receptor signaling pathways.
3. Analytical Reference Standard
Used as a certified reference material for HPLC and LC-MS. Enables accurate quantification of bile acid components in biological samples (serum, bile, feces) for pharmacokinetic, toxicological, and metabolic profiling studies.
Packaging, Safety & FAQ
What packaging options are available for bulk vs. R&D orders?
Small R&D Packs: 1g, 5g, 10g, 25g amber glass bottles (sealed, moisture-proof).
Bulk Industrial Packs: 100g, 500g, 1kg, 5kg, 10kg food-grade plastic drums/steel drums (double-sealed).
Custom OEM packaging and private labeling are available upon request.
Bulk Industrial Packs: 100g, 500g, 1kg, 5kg, 10kg food-grade plastic drums/steel drums (double-sealed).
Custom OEM packaging and private labeling are available upon request.
What are the safety handling instructions for laboratory personnel?
Although classified as non-hazardous for transport, operators must avoid direct skin, eye, and mucous membrane contact. Always wear chemical-resistant gloves, safety goggles, and a dust mask. Operate in a well-ventilated area away from open flames and static electricity.
Why choose Shaanxi Sunrise as your API intermediate supplier?
We provide a Full-Cycle QC System with in-house testing from raw materials to finished products. We guarantee Stable Bulk Supply with short lead times, tailored purity customization, and reliable global shipping with full customs clearance assistance.