98% Luteolin Powder CAS 491-70-3 | Botanical Extract Supplier
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Source high-purity 98% Luteolin yellowish-green powder (CAS 491-70-3) directly from cGMP manufacturer. HPLC verified antioxidant & soothing botanical extract.









Luteolin 98%
CAS No.: 491-70-3
Scientific Overview & Manufacturing Excellence
We specialize in the advanced botanical extraction and mass bulk supply of 98% Luteolin, a high-purity natural flavonoid monomer refined from premium Sophora japonica bud (pagoda tree flower buds). Through sophisticated low-temperature water extraction, macroporous resin enrichment, and secondary recrystallization purification technology, we produce a highly uniform yellowish-green fine powder.
The entire production workflow operates within our 100,000-class GMP dust-free closed workshops, ensuring full batch quality traceability. Every single batch is strictly calibrated via High-Performance Liquid Chromatography (HPLC) to guarantee a stable ≥98% monomer purity. We supply stable, low-impurity compliant raw materials and one-stop technical services tailored for global cosmetic factories, health food manufacturers, and biomedical research institutions.
Core Functions & Pharmacological Mechanisms
Powerful Antioxidant & Anti-Aging
Luteolin efficiently scavenges free radicals produced in the human body and skin cells. By reducing oxidative damage to tissues, it effectively delays cellular aging, preserves tissue elasticity, and significantly improves dull complexions.
Anti-Inflammatory & Sensitive Relief
By inhibiting the release of pro-inflammatory mediators, it rapidly relieves facial redness, stinging, and inflammatory discomfort caused by external stimulation, providing exceptional soothing properties for fragile skin barriers.
Broad-Spectrum Bacteriostatic Activity
It suppresses the reproduction of acne-causing bacteria, actively reducing the occurrence of inflammatory pimples and closed comedones while balancing the sebum profile of oily, acne-prone skin states.
Respiratory Tract Soothing
Acting gently on the respiratory mucosa, it eases airway hypersensitivity and dry, itchy throat discomfort, making it a functional cornerstone in improving the sub-health status of the upper respiratory tract.
Target Application Scenarios & Formulation Objectives
Sensitive & Acne Skincare
Ideal for integrating into redness relief serums, post-sun repair lotions, anti-acne essences, oil control toners, and inflammatory acne repair masks.
Throat & Systemic Health
Core active ingredient for sore throat lozenges, respiratory soothing oral solid drinks, and daily anti-aging nutritional powders.
Biomedical Laboratory Research
Deployed as a highly purified natural flavonoid standard reference substance and a reliable reagent for anti-inflammatory cell experiments.
Technical Specifications & Quality Standards
| Product Identity | Luteolin (Natural Flavonoid Monomer API) |
|---|---|
| Botanical Source | Premium Sophora japonica Bud |
| Testing Method & Purity | HPLC Analysis; ≥ 98.0% Monomer |
| Physicochemical Properties | • Appearance: Yellowish-green Fine Powder • Moisture: ≤ 5.0% • Ash Content: ≤ 4.0% • Mesh Size: 80-100 Mesh |
| Heavy Metals & Safety | Heavy Metal (Pb) ≤10ppm; Arsenic (As) ≤2ppm. Compliant with FDA/EU/GB safety standards. Low residual solvent. |
| Packaging Configurations | • Sample Scale: 1kg vacuum light-proof aluminum foil bag • Bulk Commercial: 25kg sealed light-blocking fiber drum *Private label and custom small batch specs available. |
| Storage & Shelf Life | Store sealed in a cool, dry & dark environment. Avoid high temperature & strong light. Validity is 24 months. |
Precautions & Formulation Guidelines
Light Sensitive Storage: Luteolin's flavonoid structure is sensitive to ultraviolet rays. Long-term light exposure will lead to powder discoloration and activity attenuation; it must be kept fully sealed and strictly away from light.
Solubility Matching: Slightly soluble in pure water. For water-based formulations, adding polyols such as propylene glycol and glycerin (5%-12%) as cosolvents is required to completely dissolve the powder and avoid precipitation.
Production Operation Protection: Personnel must wear dust-proof masks and gloves during weighing to prevent the inhalation of fine powder, which may cause mild respiratory discomfort.
Formula pH Adaptation: The optimal formula pH range is 4.2–7.2. A strong alkaline environment will destroy the luteolin molecular structure and severely reduce its biological efficacy.
Compatibility Restriction: Avoid simultaneous compounding with high-concentration strong oxidants, which will prematurely consume the material's antioxidant activity.
Transportation Protection: Must adopt light-proof double-layer packaging. Prevent extrusion and water seepage during transit to avoid powder agglomeration and discoloration.
Target Crowd Suggestion: Oral formulas intended for infants and pregnant women require thorough safety and stability testing prior to mass commercial production.
Frequently Asked Questions (Procurement & Quality)
What is the difference between luteolin and mixed sophora japonica bud extract?
98% luteolin is a highly purified single flavonoid monomer tested by HPLC, boasting targeted multi-effect activity. Mixed sophora bud extract is a blend of various flavonoids with low single-ingredient content, typically utilized only for mass-market, lower-cost products.
Is luteolin easy to precipitate in water-based acne essence?
Luteolin is slightly soluble in pure water. For water-based serums or toners, adding 5%-12% propylene glycol or glycerin as a cosolvent can significantly improve its solubility and completely eliminate precipitation issues.
Why must luteolin be strictly stored away from light?
The Luteolin molecular structure is inherently photosensitive. Long-term exposure to strong ambient light or UV will cause the yellowish-green powder to darken (discolor), leading to a significant drop in its antioxidant and anti-inflammatory activity.
Can you supply complete registration documents for overseas cosmetics and health food?
Yes. With extensive global export experience supplying overseas beauty brands and health food factories, we provide a full set of HPLC chromatogram reports, COAs, MSDS, and heavy metal & microbial inspection certificates to fully support your global brand filing and customs clearance.
Shaanxi Sunrise Pharmaceutical Co., Ltd.
Senior Independent Site Operations Specialist: Betty


