Lithocholic Acid (CAS 434-13-9) | 99.9% Bile Acid API Supply
Lithocholic acid raw material,CAS 434-13-9,bulk Lithocholic acid powder,Cholan-24-oic acid,secondary bile acid intermediate,VDR ligand, Shaanxi Sunrise
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⚠ STRICT REGULATORY DIRECTIVE: B2B INDUSTRIAL RAW MATERIALS ONLY
This operational facility strictly functions as a primary industrial manufacturer and supplier of active pharmaceutical ingredients (APIs) and biochemical raw materials. We do not engage in the production or distribution of finished retail dosage forms. The technical dossier below regarding Lithocholic Acid (CAS No. 434-13-9) is published exclusively for advanced lipid research, laboratory-scale biochemical engineering, and bulk pharmaceutical manufacturing procurement.
Sourcing Lithocholic Acid (CAS 434-13-9)? Why Chromatographic Purity Controls Nuclear Receptor Assays.
The Margin for Error in Secondary Bile Acid Procurement
When biochemical engineering teams draft specifications for downstream lipid metabolism profiling, structural ambiguities are fundamentally unacceptable. Lithocholic acid (LCA), chemically designated as Cholan-24-oic acid, operates as a profound endogenous signaling molecule. However, isolating this specific secondary bile acid intermediate free from isomeric contamination presents a distinct processing hurdle.
Standard extraction methodologies routinely yield trace impurities—specifically competing chenodeoxycholic or ursodeoxycholic artifacts—that skew sensitive receptor binding metrics. By managing the entire synthesis and refinement matrix internally, we supply bulk Lithocholic acid powder possessing a baseline chromatographic purity of up to 99.96%. This level of molecular clarity is engineered specifically to eliminate data noise in advanced pharmaceutical R&D.
The Molecular Target: VDR and TGR5 Ligand Applications
The commercial value of LCA extends far beyond generic digestion models. In contemporary drug discovery architectures, this cholanic acid derivative acts as a highly potent natural agonist for specific nuclear and membrane receptors. Specifically, LCA binds with remarkable affinity to the Vitamin D Receptor (VDR) and the G protein-coupled bile acid receptor 1 (TGR5).
This binding initiates distinct intracellular signaling cascades responsible for modulating energy expenditure, mitigating localized inflammation, and influencing glucose homeostasis. If a research facility procures a substandard secondary bile acid intermediate, unrecognized steroidal contaminants will competitively inhibit these precise receptor pockets. Utilizing our highly refined Lithocholic acid raw material ensures that the pharmacokinetic data generated during in vitro receptor assays reflects the true activity of LCA alone.
Defeating the Chromatographic Bottleneck
Why is genuine high-purity LCA notoriously difficult to source at scale? The primary chemical challenge lies within the hydrophobic nature of the molecule itself. Lacking a hydroxyl group at the C-7 and C-12 positions, lithocholic acid exhibits intense lipophilicity. During industrial crystallization, this physical trait causes standard raw materials to trap heavy solvent residues and aggregate undesirable lipophilic byproducts.
To defeat this bottleneck, our manufacturing facility deploys targeted gradient elution protocols coupled with advanced recrystallization phasing. We do not rely on basic titration to verify our chemical lots. Every commercial batch undergoes rigorous structural confirmation using High-Performance Liquid Chromatography (HPLC), fully cross-verified against 1H NMR (Proton Nuclear Magnetic Resonance) and Mass Spectrometry (MS). This guarantees an uncompromising batch-to-batch consistency that R&D directors can instantly rely upon for complex molecular assembly.
Technical Specification Matrix (Laboratory Grade)
For supply chain compliance officers and formulation scientists, exact analytical parameters define project viability. Review our audited release specifications below:
| Analytical Parameter | Factory Release Specification |
|---|---|
| Product Identifier | Lithocholic acid/ Cholan-24-oic acid |
| CAS Registry Number | 434-13-9 |
| Assay Purity (HPLC) | ≥ 99.0% (Routinely achieving 99.96%) |
| Molecular Formula | C24H40O3 |
| Molecular Weight | 376.57 g/mol |
| Physical Appearance | White to off-white crystalline powder |
| Structural Verification | Confirmed via 1H NMR & MS Spectral Data |
| Supply Chain Status | Direct primary manufacturer, bulk inventory ready |
Procurement FAQ: Handling and Formulation Physics
How does the lipophilicity of LCA affect solvent preparation?
Due to the absence of multiple hydroxyl groups, LCA is practically insoluble in water. Formulation engineers should default to organic solvents such as DMSO, absolute ethanol, or DMF. For cellular assays, we recommend establishing a concentrated stock solution in DMSO before executing rapid dilutions in aqueous buffers to prevent premature precipitation.
Can this intermediate be utilized as a starting material for complex steroidal synthesis?
Absolutely. Because we verify the exact position and integrity of the C-3 hydroxyl group and the C-24 carboxylic acid tail via NMR, this substrate acts as an exceptionally stable foundation for creating esterified derivatives, amide conjugates, or introducing selective metabolic tags during drug discovery.
How is batch consistency maintained for long-term clinical R&D projects?
By controlling the fundamental upstream reaction environment rather than relying on disparate brokers, our production lines yield chemically identical structures year over year. We retain master chromatograms for all dispatched lots, offering full traceability to QA departments conducting multi-year in vivo tracking.
Do you accommodate bulk commercial scaling beyond laboratory testing sizes?
Yes. As a dedicated pharmaceutical raw material manufacturer, we bridge the gap between benchtop exploration and industrial output. We routinely supply from 100-gram verification aliquots up to standard commercial drum volumes, bypassing the severe markups typical of catalog chemical distributors.