Bivalirudin Powder ≥98% CAS No: 128270-60-0
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Content
Bivalirudin - High Purity Research Grade Reagent
WARNING: This product is for laboratory pharmaceutical R&D only. NOT for human/animal clinical use, commercial drug production, or medical treatment. No clinical therapeutic efficacy claimed.
Product Name: Bivalirudin Powder
Product purity: ≥98%
CAS No: 128270-60-0
Testing Method: HPLC
Active Ingredient: Bivalirudin
Product Characteristics: White to off-white solid powder
Product Use: Only for laboratory-level pharmaceutical research, biochemical mechanism research, and drug development-related studies (not for human/animal use)
Quality Certificate: Each batch is accompanied by a complete COA (Certificate of Analysis) quality inspection report for research use
Storage Conditions: Powder: Store sealed and protected from moisture at -20°C (stable for 3 years)
Shelf Life: Unopened powder: 3 years (-20°C)
Product Description
Our Bivalirudin research-grade powder is manufactured to strict international pharmaceutical research reagent standards, featuring high purity (≥98%) and consistent batch quality. Validated by HPLC analysis, it is a white to off-white solid powder, suitable for various laboratory research applications.
Produced with stringent quality control, this product provides reliable material support for thrombin-related biochemical mechanism research, pharmaceutical R&D projects, and laboratory-level drug development studies. It is suitable for global pharmaceutical research institutions, biotech labs, and drug development teams pursuing high-quality research standards.
Pharmacological Effect (Research Reference Only)
All information below is from public academic literature, for research background reference only – no clinical efficacy claimed.
Direct Thrombin Inhibition: In research models, inhibits free and fibrin-bound thrombin (Factor IIa), blocking fibrinogen conversion to fibrin and suppressing platelet activation/aggregation in experimental systems.
Reversible & Short-Acting: In research tests, half-life ~25 minutes (simulated normal renal function); coagulation state rapidly restores post-research treatment in experimental systems.
ATIII-Independent: Effect in research systems is not affected by antithrombin III levels (experimental studies only).
Mechanism of Action (Research Reference Only)
Based on public academic research, for laboratory R&D reference only – not applicable to clinical scenarios.
Bivalirudin binds to thrombin via dual-site interaction in research models:
Catalytic Site: Blocks substrate cleavage (e.g., fibrinogen) in experimental systems.
Anion-Binding Exosite I: Enhances binding affinity and stabilizes inhibitor complexes in research systems.
Self-Limiting Property: Thrombin partially cleaves Bivalirudin's N-terminus in experimental systems, reducing over-anticoagulation risk in research models.
Research Application Scenarios (Laboratory Only)
Research value derived from public clinical references – not for clinical application.
| Research Direction | Research Value Reference (Public Literature) |
|---|---|
| PCI-related drug development | Reference material for heparin alternative research; bleeding risk mechanism studies in experimental systems |
| ACS drug R&D | Adjunct material for antiplatelet therapy mechanism research (UA/NSTEMI experimental models) |
| ECMO anticoagulation research | Mortality (OR=0.74) and thrombotic event (OR=0.52) indicator research vs. heparin in models |
| High-bleeding-risk model research | Intracranial hemorrhage risk reduction (4.9%) in elderly/renal impairment simulation models |
Comparative Advantage (Research Reference Only)
Parameters from public academic research – for laboratory material selection reference only (non-clinical).
| Research Parameter | Bivalirudin (Research Reference) | Heparin (Research Reference) |
|---|---|---|
| Bleeding risk (research model) | Lower in experimental systems | Higher in experimental systems |
| HIT risk (research model) | No related risk (HIT model research material) | Requires indicator monitoring in experimental systems |
| Anticoagulation control | Short half-life; rapid reversal in research systems | Variable response; protamine reversal research in models |
| Thrombin inhibition | Inhibits free + fibrin-bound thrombin (experimental) | Inhibits free thrombin only (experimental) |
Core Advantages
High Purity: ≥98% research-grade purity, validated by HPLC – suitable for a wide range of laboratory research.
Strict Quality Control: Each batch is accompanied by a complete COA (Certificate of Analysis), ensuring transparency and reliability for your research.
Stable and Long-Lasting: Stable for 3 years when stored sealed and protected from moisture at -20°C, providing a long shelf life for research planning.
Clear Identification: A white to off-white solid powder, making it easy to handle and identify in the laboratory setting.
Compliant Supply: Exclusively for qualified research institutions, ensuring a compliant and secure supply chain for your research materials.
Important Research Use Statement
Usage Restriction: For laboratory pharmaceutical R&D only – prohibited for human/animal clinical use, commercial drug production, or medical diagnosis.
Data Reference: All research data/parameters are from public literature – no guarantee of research result consistency.
Responsibility: Illegal/improper use (e.g., clinical use) leading to research errors or consequences is the user's sole responsibility.
Research Independence: Lab results depend on experimental conditions – no guarantee of alignment with public reference data.
Quality Scope: Research-grade quality only – does not meet commercial drug production/clinical application standards.
FAQ (For Research Use Only)
Q1: How to obtain the COA quality report?
A: Each batch includes a full COA report. Contact customer service with your order number to receive the electronic report, or verify via our official website's qualification portal.
Q2: What are the key storage requirements?
A: The powder must be stored sealed and protected from moisture at -20°C. Under these conditions, it is stable for 3 years from the date of manufacture (unopened).
Q3: Who is eligible to purchase this product?
A: Only qualified pharmaceutical R&D institutions (pharma companies, biotech labs, university research depts). Individuals are not accepted. Provide research project certificate + business license for registration.
Q4: Can it be used for in vitro/in vivo animal experiments?
A: For in vitro lab research only. For animal experiments, obtain ethical approval – all experimental risks are the purchaser's responsibility (no animal experiment technical support provided).
Q5: What is the appearance of the product?
A: The product is a white to off-white solid powder, which is clearly stated in the product specifications and verified in the COA for each batch.